HMCS Antigonish was a River-class frigate that served in the Royal Canadian Navy from 1944–1946 and as a Prestonian-class frigate from 1957–1966.

She is named for Antigonish, Nova Scotia. Her photo is featured on the cover of the 1994 album Frigate by the band April Wine.

Antigonish was ordered 1 February 1943 as part of the 1943–44 River-class building programme. She was laid down by Yarrows Ltd. at Esquimalt on 2 October 1943 and launched 10 February 1944. She was commissioned at Esquimalt into the RCN on 4 July 1944 with the pennant K661